Novosti
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This journal is indexed in Scopus |
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Year 2022 Vol. 30 No 5
SCIENTIFIC PUBLICATIONS
A.T. SHCHASTNY, A.S. OSOCHUK, A.F. MARTSINKEVICH, S.S. OSOCHUK
THE EFFECT OF TACROLIMUS ON THE DYNAMICS OF CHANGES IN THE PARAMETERS OF CELLULAR IMMUNITY IN THE EARLY STAGES AFTER KIDNEY TRANSPLANTATION
Vitebsk State Medical University, Vitebsk,
Republic of Belarus
Objective. To study the effect of tacrolimus on the dynamics of changes in some paramerters of cellular immunity after kidney transplantation in men and women.
Methods. The study included people (n=28) of both sexes (15 men and 13 women of the second period of adulthood (36-60 years – men and 36-55 years – women)) with kidney transplantation due to chronic renal failure. Venous blood was taken at admission (before surgery), after surgery (before the first appointment of tacrolimus), 24 hours and 7 days after kidney transplantation. For flow cytometer analysis, samples were processed in the first 4 hours after the collection.
Results. In women with chronic renal failure in the preoperative period, the number of dendritic cells is lower than in men. After kidney transplantation, a decrease of the number of myeloid and lymphoid dendritic cells, a decrease of the number of total T-lymphocytes due to T-helpers, and an increase of the number of natural killers have been revealed. The application of tacrolimus returned the number of total T-lymphocytes to preoperative values due to T-helpers and reduced the number of natural killers, increased the number of pre-B and B-lymphocytes.
Conclusion. The observed dynamic changes in cellular immunity parameters after kidney transplantation may be favorable for graft survival. However, the increase of the number of CD3 + CD4 + after the appointment of tacrolimus, as well as the increase of the content of CD19, requires further research to classify the identified effects as positive or negative.
- Kliem V, Nabokov AV. Tacrolimus in base immunosuppression after renal transplantation: reasons, dosing and management. Nephrology (Saint-Petersburg). 2007;11(4):95-98. (In Russ.) doi: 10.24884/1561-6274-2007-11-4-95-98
- Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991;66(4):807-15. doi: 10.1016/0092-8674(91)90124-h
- Stuetz A, Grassberger M, Meingassner JG. Pimecrolimus (Elidel, SDZ ASM 981)--preclinical pharmacologic profile and skin selectivity. Semin Cutan Med Surg. 2001;20(4):233-41. doi: 10.1053/sder.2001.29066
- Tornatore KM, Meaney CJ, Attwood K, Brazeau DA, Wilding GE, Consiglio JD, Gundroo A, Chang SS, Gray V, Cooper LM, Venuto RC. Race and sex associations with tacrolimus pharmacokinetics in stable kidney transplant recipients. Pharmacotherapy. 2022;42(2):94-105. doi: 10.1002/phar.
- He Y, Ma Y, Fu Q, Liang J, Yu X, Huang H, Zhong L, Huang B. The CYP3A5 and ABCB1 Gene Polymorphisms in Kidney Transplant Patients and Establishment of Initial Daily Tacrolimus Dosing Formula. Ann Pharmacother. 2022;56(4):393-400. doi: 10.1177/
- Bunak VV. Allocation of stages of ontogenesis and chronological boundaries of age periods. In book: Bunak VV. Sovetskaja pedagogika. 1965;11:105-119. (In Russ.)
- Bates D, Machler M, Bolker B. Walker S. Fitting Linear Mixed-Effects Models Using lme4. J. Stat. Softw. 2015; 67(1):1-48. doi: 10.18637/jss.v067.i01
- Searle SR, Speed FM, Milliken GA. Population Marginal Means in the Linear Model: An Alternative to Least Squares Means. Am. Stat. 1980; 34(4): 216-21. doi: 10.1080/00031305.1980.10483031
- Hesselink DA, Vaessen LM, Hop WC, Schoordijk W, Ijzermans JN, Baan CC, Weimar W. The effects of renal transplantation on circulating dendritic cells. Clin Exp Immunol. 2005;140(2):384-93. doi: 10.1111/j.1365-2249.2005.02755.x
- Shodell M, Siegal FP. Corticosteroids depress IFN-alpha-producing plasmacytoid dendritic cells in human blood. J Allergy Clin Immunol. 2001;108(3):446-48. doi: 10.1067/mai.2001.117928.
- Roelen DL, Schuurhuis DH, van den Boogaardt DE, Koekkoek K, van Miert PM, van Schip JJ, Laban S, Rea D, Melief CJ, Offringa P, Ossendorp F, Claas FH. Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells. Transplantation. 2003;76(11):1608-15. doi: 10.1097/01.TP.0000086340.30817.BA
- Mirenda V, Berton I, Read J, Cook T, Smith J, Dorling A, lan Lechler R. Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation. J Am Soc Nephrol. 2004;15(4):987-97. doi: 10.1097/01.asn.0000119575.98696.1d.
- Kogina K, Shoda H, Yamaguchi Y, Tsuno NH, Takahashi K, Fujio K, Yamamoto K. Tacrolimus differentially regulates the proliferation of conventional and regulatory CD4(+) T cells. Mol Cells. 2009;28(2):125-30. doi: 10.1007/s10059-009-0114-z
- Hirose T, Iwami D, Hotta K, Sasaki H, Higuchi H, Shinohara N. Percentage of CD19+ Cells in Peripheral Blood Lymphocytes After Rituximab-Based Desensitization as a Predictor of Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation. Transplant Proc. 2019;51(5):1382-86. doi: 10.1016/j.transproceed.2019.01.127
- Takahashi K, Saito K. ABO-incompatible kidney transplantation. Transplant Rev (Orlando). 2013;27(1):1-8. doi: 10.1016/j.trre.2012.07.003
- Wai LE, Fujiki M, Takeda S, Martinez OM, Krams SM. Rapamycin, but not cyclosporine or FK506, alters natural killer cell function. Transplantation. 2008;85(1):145-49. doi: 10.1097/01.tp.0000296817.28053.7b.
- Kitchens WH, Uehara S, Chase CM, Colvin RB, Russell PS, Madsen JC. The changing role of natural killer cells in solid organ rejection and tolerance. Transplantation. 2006;81(6):811-17. doi: 10.1097/01.tp.0000202844.33794.0e
- Miyairi S, Baldwin WM 3rd, Valujskikh A, Fairchild RL. Natural Killer Cells: Critical Effectors During Antibody-mediated Rejection of Solid Organ Allografts. Transplantation. 2021;105(2):284-90. doi: 10.1097/TP.0000000000003298
210009, Republic of Belarus,
Vitebsk, ave. Frunze, 27,
Vitebsk State Medical University,
Department of Hospital Surgery
with the Course of Advanced Training,
tel. +375-29-595-04-03,
e-mail: aos19950207@gmail.com,
Osochuk Alexander S.
Shchastny Anatoly Tadeushevich, MD, Professor, Rector of the Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0003-2796-4240
Osochuk Aleksandr Sergeevich, Post-Graduate Student of the Department of Hospital Surgery with the Course of Advanced Training, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0002-5942-3601
Martsinkevich Alexander Frantsevich, PhD, Associate Professor of the Department of General and Clinical Biochemistry with the Course of Advanced Training, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0003-3655-4489
Osochuk Sergey Stefanovich, MD, Professor, Head of the Research Laboratory of VSMU, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0003-2074-3832