Year 2022 Vol. 30 No 5

SCIENTIFIC PUBLICATIONS

A.T. SHCHASTNY, A.S. OSOCHUK, A.F. MARTSINKEVICH, S.S. OSOCHUK

THE EFFECT OF TACROLIMUS ON THE DYNAMICS OF CHANGES IN THE PARAMETERS OF CELLULAR IMMUNITY IN THE EARLY STAGES AFTER KIDNEY TRANSPLANTATION

Vitebsk State Medical University, Vitebsk,
Republic of Belarus

Objective. To study the effect of tacrolimus on the dynamics of changes in some paramerters of cellular immunity after kidney transplantation in men and women.
Methods. The study included people (n=28) of both sexes (15 men and 13 women of the second period of adulthood (36-60 years – men and 36-55 years – women)) with kidney transplantation due to chronic renal failure. Venous blood was taken at admission (before surgery), after surgery (before the first appointment of tacrolimus), 24 hours and 7 days after kidney transplantation. For flow cytometer analysis, samples were processed in the first 4 hours after the collection.
Results. In women with chronic renal failure in the preoperative period, the number of dendritic cells is lower than in men. After kidney transplantation, a decrease of the number of myeloid and lymphoid dendritic cells, a decrease of the number of total T-lymphocytes due to T-helpers, and an increase of the number of natural killers have been revealed. The application of tacrolimus returned the number of total T-lymphocytes to preoperative values due to T-helpers and reduced the number of natural killers, increased the number of pre-B and B-lymphocytes.
Conclusion. The observed dynamic changes in cellular immunity parameters after kidney transplantation may be favorable for graft survival. However, the increase of the number of CD3 + CD4 + after the appointment of tacrolimus, as well as the increase of the content of CD19, requires further research to classify the identified effects as positive or negative.

Keywords: tacrolimus, kidney transplantation, dendritic cells, natural killers, T-lymphocytes, B-lymphocytes
p. 434-439 of the original issue
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Address for correspondence:
210009, Republic of Belarus,
Vitebsk, ave. Frunze, 27,
Vitebsk State Medical University,
Department of Hospital Surgery
with the Course of Advanced Training,
tel. +375-29-595-04-03,
e-mail: aos19950207@gmail.com,
Osochuk Alexander S.
Information about the authors:
Shchastny Anatoly Tadeushevich, MD, Professor, Rector of the Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0003-2796-4240
Osochuk Aleksandr Sergeevich, Post-Graduate Student of the Department of Hospital Surgery with the Course of Advanced Training, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0002-5942-3601
Martsinkevich Alexander Frantsevich, PhD, Associate Professor of the Department of General and Clinical Biochemistry with the Course of Advanced Training, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0003-3655-4489
Osochuk Sergey Stefanovich, MD, Professor, Head of the Research Laboratory of VSMU, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0003-2074-3832
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