Novosti
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Year 2013 Vol. 21 No 5
GENERAL AND SPECIAL SURGERY
Y.P. ORLOV1, V.N. LUKACH1, A.V. GLUSCHENKO1,2
REAMBERIN IN THE INTENSIVE THERAPY PROGRAM IN PATIENTS WITH GENERALIZED PERITONITIS
SBEE HPE "Omsk State Medical Academy"1,
Omsk Municipal Clinical Emergency Hospital2,
The Russian Federation
Objectives. To determine reamberin efficiency in the intensive therapy program of generalized peritonitis (GP) for correction of the rheological disorders, providing of effective oxygen supply to tissues, restoration of oxidative phosphorylation and tissue reparation.
Methods. 24 patients with GP were included in the study (severe abdominal sepsis) due to destructive appendicitis, perforated gastric and duodenal ulcers. 2 groups were formed in the postoperative period. The main group (n=12) consisted of 6 men (aged of 31,4±3,3 years (M±σ)) and 6 women (aged 32,4±2,4 years (M±σ)) with GP (according to Mannheim scale 30,4±2,1 scores (M±σ)) where reamberin was used in the program of the infusion therapy. The comparison group (n=12) consisted of 4 men (34,3±3,1 years scores (M±σ)) and 8 women (31,4±2,6 years (M±σ)) with GP (according to Mannheim scale 30,1±3,2 year scores (M±σ)) where reamberin was not used.
Results. The use of reamberin in patients with GP reduces (60%) intensity of processes of free radical oxidation (FRO) and lipid peroxidation (LP) (reduction of MD (malonic dialdehyde in 2-fold), reduces the tissue hypoxia (in 3,8-fold). It generally contributes to the reduction of mortality, the terms of vasopressor support (in 1,5-fold), artificial pulmonary ventilation (APV) and decrease the hospitalization period of patients at the Intensive Care Unit (in 1,2-fold).
Conclusions. The conducted study confirms the efficiency of reamberin use in patients with GP due to its elimination of metabolic acidosis, improving the rheological properties of the blood and oxygen supply to the tissues at the expense of normalizing of the red blood cells volume, restoration of microcirculation, intestinal motility, realize an earlier enteral nutrition, improving of reparative processes and suturing of the laparotomic wound in the early postoperative period.
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644119, Rossiiskaia Federatsiia, g. Omsk, ul. Pereleta d. 9, GKB № 1, GBOU VPO Omskaia gosudarstvennaia meditsinskaia akademiia, kafedra anesteziologii i reanimatologii,
e-mail: orlov-up@mail.ru,
Orlov Yurii Petrovich
Orlov Y.P. MD, professor of the chair of anesthesiology and critical care medicine of SEI HPE "Omsk State Medical Academy".
Lukach V.N. An Honored Worker of Higher School, MD, a head of the department of anesthesiology and intensive care of SEI HPE "Omsk State Medical Academy".
Gluschenko A.V. PhD, an assistant of the chair of anesthesiology and intensive care of SEI HPE "Omsk State Medical Academy", a head of the intensive care unit for septic patients of Omsk Municipal Clinical Emergency Hospital.
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