Year 2013 Vol. 21 No 6

ANESTHESIOLOGY-REANIMATOLOGY

A.V. MARACHKOU, A.L. LIPNITSKI

THE USE OF MAGNESIUM SULFATE TO POTENTIATE EFFECT OF LOW DOSES OF ROCURONIUM: A RANDOMIZED STUDY

ME “Mogilev Regional Hospital”,
The Republic of Belarus

Objectives. To investigate the effect of magnesium sulfate during the onset time of rocuronium action, making conditions for the trachea intubation and find out the effect duration of rocuronium (low doses).
Methods. Thirty patients (aged of 18-70 yrs.) underwent the laparoscopic cholecystectomy were enrolled in the study. All patients received rocuronium 0,3 mg/kg. Rocuronium dosage in all patients was calculated for the ideal body weight according to Lorentz formula. Control of neuromuscular transmission was measured according to Stockholm criteria for the pharmacodynamic studies of myorelaxants action. The patients were injected 45 mg/kg of MgSO4 (the 1st group) or the same volume of physiological solution (the 2nd group). The indicated drugs were given intravenously through syringe dispenser within 5 minutes and 1 minute after finishing the injections the induction in anesthesia was began.
Results. Onset time of rocuronium action was significantly less when magnesium sulfate was used and made up 90 seconds (80-140) (Me (25%-75%)) in the 1st group and 240 seconds (120-300) in the 2nd group (p<0,05, Mann-Whitney Test). Tracheal intubation was performed in all patients during 90-120 seconds from the first attempt. Five patients in the 2nd group had poor intubating conditions versus none in the magnesium group (p<0,05, χ2-test). Duration of rocuronium action didn’t differ between the groups and composed 25 min (22-30) in the 1st group and 27,5 min (22,5-33) in 2nd group (p>0,05).
Conclusions. Magnesium sulfate in the dose of 45mg/kg accelerates onset of rocuronium (low doses) action as well as improves the conditions for trachea intubation but does not prolong the action duration.

Keywords: muscle relaxants, rocuronium, magnesium sulfate, neuromuscular block, general anesthesia
p. 98 – 104 of the original issue
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Address for correspondence:
212002, Respublika Belarus', g. Mogilev, ul. B. Biruli d. 12, UZ «Mogilevskaia oblastnaia bol'nitsa», otdelenie transplant-koordinatsii,
e-mail: Lipnitski.al@gmail.com,
Lipnitski Artur Leonidovich
Information about the authors:
Marachkou A.V. MD, professor, a head of the intensive care unit of ME “Mogilev Regional Hospital”.
Lipnitski A.L. A head of the transplant and coordination department of ME “Mogilev Regional Hospital”.
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