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Year 2011 Vol. 19 No 6

EXPERIMENTAL SURGERY

V.А. КOSINETS, I.V. SAMSONOVA, E.L. RYZHKOVSKAYA IN THE LIVER AT THE EXPERIMENTAL WIDESPREAD

STRUCTURAL CHANGES IN THE LIVER AT THE EXPERIMENTAL WIDESPREAD PURULENT PERITONITIS

Objectives. To study structural changes in the liver using light and electronic microscopy and the ways of its correction at an experimental widespread purulent peritonitis.
Methods. The structural changes in the liver using light and electronic microscopy were studied during the experiment on 55 male rabbits of chinchilla breed at the experimental widespread purulent peritonitis.
Results. In 6 hours after initiation of peritonitis in the liver the hemodynamic disorders, interstitional edema, severe inflammatory neutrophilic parenchyma infiltration were observed. In the majority of hepatocytes dystrophic, necrobiotic and necrotic changes were defined. Intensive mitochondrial destruction testified to the deficiency of the hepatocytes power maintenance.
Conclusions. The comparative analysis of action of metabolic preparations "Citoflavin" which contains amber acid and "Neoton" containing phosphocreatine on a structural condition of the liver at the experimental widespread purulent peritonitis has revealed high efficiency of the preparation "Citoflavin". The last one provided intensive restoration of the liver structure, decrease of inflammatory changes and preservation of integrity of mitochondrions.

Keywords: widespread purulent peritonitis, heart, structural changes, mitochondria, «Neoton», «Citoflavin»s
p. 8 – 14 of the original issue
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