Novosti
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This journal is indexed in Scopus |
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Year 2017 Vol. 25 No 6
ONCOLOGY
Y.B. RADZISHEVSKA 1,2, L.Y. VASIL’EV 1, V.G. KNIGAVKO 2, N.I. LYKHOVITSKAYA 1
RELATIONSHIPS OF NOSOLOGICAL FORM OF THE PRIMARY AND SECOND NEOPLASMS IN ONCOLOGICAL PATIENTS
SE “Institute of Medical Radiology named after S.P. Grigoriev”
of the National Academy of Medical Sciences of Ukraine 1,
Kharkov National Medical University 2, Kharkov,
Ukraine
Objective. To investigate the relationship between nosological forms of the primary and second neoplasms in patients who have undergone special treatment for cancer, and who have developed second neoplasms three and more years after the end of treatment.
Methods. The study has compared the nosological structure of second neoplasms that developed in 203 patients undergoing treatment for oncological pathology with the official data on the specific weight of 10 major nosological forms of malignant neoplasms in Ukraine. The statistical significance of the obtained results has been estimated using confidence intervals normalized taking into account the specificity of the patients of the clinic where the study was conducted.
Results. In accordance with the specific weight of the nosological forms of the primary neoplasms, conditioned first by the specialization of the clinic, the study groups were divided into 5 nosological subgroups: patients with breast, thyroid, uterine, cervical, ovarian, and subgroup with other forms of cancer. For each of the subgroups, the nosological structure of the second neoplasms was investigated and compared with the overall structure of malignant neoplasms according to the official statistics. It is shown that the frequencies of five allocated nosological forms calculated for the clinic correspond fairly well to the population mean, while for two most representative nosological forms the correspondence is within the expected stochastic variability. Thus, it has been demonstrated that there are no statistically significant differences between the percentage composition of 10 major nosological forms of cancer in Ukraine and the structure of nosological forms of second neoplasms in the study group of patients.
Conclusions. The nosological form of second neoplasms is not a consequence of the primary cancer, but reproduces the overall nosological structure of the incidence of malignant neoplasms.
- Alberts D. Second cancers are killing us. Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(Is 11): 2019. doi: 10.1158/1055-9965.EPI-06-0417.
- Rowland J, Mariotto A, Aziz N, Tesauro G, Feuer EJ, Blackman B, et al. Cancer survivorship–United States, 1971-2001. MMWR Morbid Mortal Wkly Rep. 2004 Jun 25;53(24):526-29.
- Berrington de Gonzalez A, Curtis RE, Gilbert E, Berg CD, Smith SA, Stovall M, et al. Second solid cancers after radiotherapy for breast cancer in SEER cancer registries. Br J Cancer. 2010 Jan 5;102(1):220-26. doi: 10.1038/sj.bjc.6605435.
- Virtanen A, Pukkala E, Auvinen A. Angiosarcoma after radiotherapy: a cohort study of 332 163 Finnish cancer patients. Br J Cancer. 2007 Jul 2; 97(1): 115-17. doi: 10.1038/sj.bjc.6603805.
- Maksimov SI. Pervichno-mnozhestvennye opukholi organov reproduktivnoi sistemy [Primary-multiple tumors of organs of the reproductive system]. Prakt Onkologiia. 2009;10(2):117-23.
- Kakinuma S, Shimada Y. Risk of second cancer after radiation therapy. Igaku Butsuri. 2014;34(2):79-84. [Article in Japanese]
- Ota T, Takeshima IN., Tabata IT, Hasumi 1K, Takizawa K. Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers. Br J Cancer. 2007 Oct 22;97(8): 1058-62. doi: 10.1038/sj.bjc.6604005.
- Ganz PA. A teachable moment for oncologists: cancer survivors, 10 million strong and growing! J Clin Oncol. 2005 Aug 20;23(24):5458-60.
- Vogel VG. Identifying and screening patients at risk of second cancers. Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2027-32.
- Lischko AM, Seddon JM, Gragoudas ES, Egan KM, Glynn RJ. Evaluation of prior primary malignancy as a determinant of uveal melanoma. A case-control study. Ophthalmology. 1989 Dec;96(12):1716-21.
- Bernshtein LM, red. Gormonal’nyi kantserogenez [Hormonal carcinogenesis]. S-Peterburg, RF: Nauka; 2000. 199 p.
- Bokhman IV, Rybin EP, Polineoplazii organov reproduktivnoi sistemy [Polyneoplasia of the organs of the reproductive system]. S.-Peterburg, RF: Neva-Liuks; 2001. 240 p.
- Ackerman J, Baunoch DA, Gimotty P, George J, Lane MA, Dawson PJ. The role of p53 mutations in bilateral breast carcinoma. Mod Pathol. 1995 Apr;8(3):244-48.
- Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012 Jan;5(1):9-19. doi: 10.1097/WOX.0b013e3182439613.
- Abe H, Hanasawa K, Naitoh H, Endo Y, Tani T, Kushima R. Invasive ductal carcinoma within a fibroadenoma of the breast. Int J Clin Oncol. 2004 Aug;9(4):334-38.
- Schaapveld M, Aleman BM, van Eggermond AM, Janus CP, Krol AD, van der Maazen RW, et al. Second cancer risk up to 40 years after treatment for Hodgkin’s Lymphoma. N Engl J Med. 2015 Dec 24;373(26):2499-511. doi: 10.1056/NEJMoa1505949.
- Grantzau T, Mellemkjær L, Overgaard J. Second primary cancers after adjuvant radiotherapy in early breast cancer patients: a national population based study under the Danish Breast Cancer Cooperative Group (DBCG). Radiother Oncol. 2013 Jan;106(1):42-49. doi: 10.1016/j.radonc.2013.01.002.
61024, Ukraine,
Kharkov, Pushkinskaya str., 82,
SE «Institute of Medical Radiology
named after S.P. Grigoriev»,
Medical Informatics Group,
tel. office: +380 (67) 799-36-63,
e-mail: radzishevska@ukr.net,
Evgeniya B. Radzishevska
Radzishevska E.B., PhD, Head of the Medical Informatics Group of SE “Institute of Medical Radiology named after S.P. Grigoriev “of the National Academy of Medical Sciences of Ukraine, Associate Professor of the Department of Medical and Biological Physics and Medical Informatics of Kharkov National Medical University.
Vasil’ev L.Y., PhD, Head Physician of SE “Institute of Medical Radiology named after S.P. Grigoriev “of the National Academy of Medical Sciences of Ukraine.
Knigavko V.G., Doctor of Biological Sciences, Professor, Head of the Department of Medical and Biological Physics and Medical Informatics of Kharkov National Medical University.
Lykhovitskaya N.I., PhD, Researcher of the Nuclear Medicine Department of SE “Institute of Medical Radiology named after S.P. Grigoriev “of the National Academy of Medical Sciences of Ukraine.
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