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Khirurgii
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Year 2007 Vol. 15 No 4

ORIGINAL INVESTIGATIONS

MARKAUTSAN P.V., BAYESHKO A.A., ARCHAKOVA L.I.

VEIN INTIMA CHANGES IN BLOOD FLOW RETARDATION IN THE EXPERIMENT

Blood flow retardation in the early period (the first minutes – days) causes intima damage due to hypoxia and transendothelial leukocyte migration. Leukocytes have been located along the inner vein coat by the 5th minute of the experiment, during the 15th minute they are massively infiltrating its wall. Swelling and focal disturbance of endothelium integrity (mainly of cytoplasm cell part) are observed as well as inner elastic membrane fragmentation. The number of microvilli increases chiefly on the endotheliocytes apical surface. The collagenous fibers content increases in the subendothelial layer. In several cases formation of «microthrombi», consisting of single leukocytes and thrombocytes, adhesived to the vein luminal surface, takes place. At the same time adaptation processes occur actively in intima, aimed to minimize the damages and to restore its ultra structure.

Keywords: blood flow retardation, rat’s femoral vein, leukocytes.
p. 42 - 47 of the original issue
References
  1. Баешко, А. А. Послеоперационный тромбоз глубоких вен нижних конечностей и тромбоэмболия легочной артерии / А. А. Баешко. – М., 2000.
  2. Зайчик, А. Ш. Основы общей патологии. Основы общей патофизиологии: учебное пособие / А. Ш. Зайчик, Л. П. Чурилов. – СПб., 1999. – Ч. 1.
  3. Руководство по гистологии / под ред. Р. К. Данилова. – СПб., 2001. – Т. 1.
  4. Уикли. Б. Электронная микроскопия для начинающих: пер. с англ. / Б. М. Уикли. – 1975.
  5. В. А. Шахламов [и др.] // Морфология. – 2000. – № 5. – С. 25–29.
  6. Benard, E. // Presse Med. / E. Benard, A. Lafuma, P. Ravaud. – 2005. – Vol. 34, N 6. – P. 415–419.
  7. C. Closse [et al.] // Thromb. Res. – 1997. – Vol. 85. – P.159–164.
  8. C. L. Klein [et al.] // Pathobiology. – 1995. – Vol. 63, N 1. – Р. 1–8.
  9. Reynolds, E. S. // J. Cell. Biol. – 1963. – Vol.17. – N 2. – P. 208–210.
  10. S. S. Signorelli [et al.] // Clin. Hemorheol. Microcirc. – 2000. – Vol. 22, N 4. – P. 311–316.
  11. Stewart, G.J. // Haemostatasis. – 1993. – Vol. 23. – P. 127–140.
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