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Year 2019 Vol. 27 No 1
R.V. KARPOVA, A.F. CHERNOUSOV, Ò.V. KHOROBRYH, D.A. KAZAKOVA, YU.M. POLUEKTOV
LIVER REGENERATION AFTER INTRAHEPATIC INJECTION OF CRYOPRECIPITATE IN A PATIENT WITH CIRRHOSIS
I.M. Sechenov First Moscow State Medical University, Moscow,
The Russian Federation
Nowadays the mortality rate due to the liver cirrhosis has been steadily increasing. Conservative methods of treatment have a positive effect at an early stage of the disease in some patients. The amount of five-year survival rate is 62% in the compensation stage of cirrhosis whereas it decreases to 19% at the decompensation stage. At the present time, the most effective treatment of cirrhosis is liver transplantation because a five-year survival rate is 70-75%. However, this method is followed by the number of limitations. In this aspect, we give preference to minimally invasive techniques with the use of agents influencing an inflammation process and liver regeneration. This case report describes the clinical experience of seven-year observation of the patient with viral liver cirrhosis (HbsAg+, DNA HBV+, HDV+) in the decompensation stage (C-class by Child-Pugh) treated by the minimally invasive method: intrahepatic injection of cryoprecipitate. This contributed to the improvement of the general state and clinical and laboratory parameters for a long time. The cryoprecipitate is a highly concentrated solution of fibrinogen derived from donor plasma by cryoprecipitation, containing growth factors to decrease macrophage activity and cirrhosis progress. On admission, the patient had the unfavorable prognosis for the disease. However, the usage of cryoprecipitate showed significant improvement of the laboratory and hemodynamic tests. The effectiveness and availability of this method make it perspective for the treatment of the patients with liver cirrhosis in the stage of decompensation.
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119435, The Russian Federation,
Moscow, B. Pirogovskaya Str., 6-1,
I.M. Sechenov First Moscow
State Medical University,
Department of Faculty Surgery ¹1.
Tel.: +7 916 407-75-70,
Yuri M. Poluektov
Karpova Radmila V., MD, Professor of the Department of Faculty Surgery ¹1, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Chernousov Alexander F., Academician of RAS, MD, Professor, Head of the Department of Faculty Surgery ¹1, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Khorobryh Tatiana V., MD, Professor of the Department of Faculty Surgery ¹1, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Kazakova Daria A., 5-Year Student of the Faculty “Medicine of Future”, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Poluektov Yuri M., 5-Year Student of the Faculty “Medicine of Future”, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.