Year 2012 Vol. 20 No 1




SE Institute of General and Emergency Surgery of AMSU 1, Kharkov,
the Ukraine
Azerbaijan Medical University2, Baku,
the Republic of Azerbaijan

Objectives. To study the ferroproteins level in the blood plasma and peritoneal exudate in patients with the widespread peritonitis and possibility of their application as clinical-diagnostic and prognostic marker of acute inflammation.
Methods. 60 patients with the widespread peritonitis were investigated. LF and FR content in the blood plasma and peritoneal exudates was determined by ELISA in dynamics before the operation and 1, 3, 5, 7 days after the operation. Severity of patients state was determined by means of Manheim peritoneal index: in 17 patients it was MPI I, in 23 patients - MPI II, in 20 patients - MPI III. Complex conventional treatment was carried out in all patients including surgical sanitation and drainage of the abdominal cavity, decompression of the gastrointestinal tract and conservative therapy. 15 practically healthy subjects were included into the control group.
Results. Distinct dependence of LF and FR concentration in the blood plasma and exudate was established depending on the severity degree of the patients with the widespread peritonitis according to MPI. Complete level correlation of both ferroproteins in the plasma with their level in the separated exudate along the drainages was revealed.
Conclusions. Determination of lactoferrin and ferritin in biological media in patients with the widespread peritonitis can be used as biomarkers of inflammatory process intensiveness as well as to evaluate severity of ones state and adequacy of treatment.

Keywords: peritonitis,ferroproteins, lactoferrin, ferritin
p. 67 70 of the original issue

1.Nazarov PG. Reaktanty ostroi fazy vospaleniia [Acute phase reactants of inflammation]. Saint-Petersburg, RF: Nauka; 2001. 423 p.
2.Al-Delaimy WK, Jansen EH. Reliability of biomarkers of iron status, blood lipids, oxidative stress, vitamin D, C reactive protein and fructosamine in two Dutch cohorts. Biomarkers. 2006;11(4):37082.
3.Kondo K, Noguchi M, Mukai K, Matsuno Y, Sato Y, Shimosato Y, Monden Y. Transferrin receptor expression in adenocarcinoma of the lung as a histopathologic indicator of prognosis. Chest. 1990 Jun;97(6):136771.
4.Belaia OL. Vliianie bioflavonoida dikvertina na antioksidantnuiu sistemu tseruloplazmin/transferritin i perekisnoe okislenie lipidov u bol'nykh stabil'nymi formami ishemicheskoi bolezni serdtsa s dislipidemiei [Effect of bioflavonoid diquertin on antioxidant system ceruloplasmin / transferritin and lipid peroxidation in patients with stable coronary heart disease with dyslipidemia]. Klin Med. 2006;(7):4650.
5.Orino K, Tsuji Y, Torti F, Torti S. Adenovirus E1A blocks oxidant-dependent ferritin induction and sensitizes cells to pro-oxidant cytotoxicity. FEBS Lett. 1999;461:33438.
6.Bokeriia LA, Golukhova EZ, Chichkova MA. Ostrofazovye markery patologicheskogo protsessa v prognozirovanii kharaktera klinicheskogo techeniia ekssudativnogo perikardita posle kardiokhirurgicheskikh vmeshatel'stv [Acute-phase markers of the pathological process in the prediction of clinical course of exudative pericarditis after cardiac surgery]. Sovrem Meditsina: Teoriia i Praktika. 2004;(4):28.
7.Iliukevich GV, Smirnova LA. Ferroproteiny kak markery sistemnogo vospalitel'nogo otveta pri ostrom rasprostranennom peritonite [Ferroproteins as markers of systemic inflammatory response in acute generalized peritonitis]. Vestsi NAN Belarusi Ser Med -Biol Navuk. 2002;(2):2325.
8.Lakin G.F. Biometriia [Biometrics]. Moscow, RF: Vysh shk; 1990. 352 p.

Address for correspondence:
AZ 1022, Azerbaidzhanskaia Respublika, g. Baku, ul. Bakikhanova, d. 23, Azerbaidzhanskii meditsinskii universitet, kafedra khirurgicheskikh boleznei pediatricheskogo fakul'teta,
Hadjiyev Novruz Dzhabbar ogly
Information about the authors:
Sushkov S.V. Doctor of medical sciences, professor, vice-rector on scientific work of SE Institute of general and urgent surgery of AMS of the Ukraine.
Nasirov M.YA. Doctor of medical sciences, Honored scientist, professor of the chair of surgical diseases, vice-rector of Azerbaijan Medical University.
HadjiyeV H.J.Candidate of medical sciences, senior laboratory assistant of the chair of surgical diseases of Azerbaijan Medical University, applicant for Doctors degree of SE Institute of general and urgent surgery of AMS of the Ukraine.
Contacts | ©Vitebsk State Medical University, 2007-2023